![]() To keep the embryos alive after fertilizing or injecting them, they would need to be transplanted into another female mouse, as well. Mouse embryos develop inside the mother, and to access and manipulate them the mother would have to be sacrificed. Working with mice in this way is much more complicated. The one-cell-stage fertilized eggs can be easily injected with DNA or RNA to permanently modify their genetic makeup in order to generate transgenic or knock-out zebrafish lines. In vitro fertilization can be performed if necessary. Zebrafish embryos are also laid and fertilized externally, which allows them to be easily manipulated in a variety of ways. Scientific experiments are generally repeated multiple times in order to prove that the results are accurate, so having an animal that can produce a large number of offspring over and over is helpful. This is quite different from mice as they generally produce litters of one to 10 pups and can only bear approximately three litters in their lifetime. The NIH Zebrafish Core houses hundreds of thousands of zebrafish in a state-of-the-art facility.Īnother advantage is that adult zebrafish breed readily (approximately every 10 days) and can produce as many as 50 to 300 eggs at a time. As a result, they require much less space and are cheaper to maintain than mice. One important advantage of zebrafish is that the adults are small and prefer to be housed in large groups, or “shoals”. ![]() While mice are evolutionarily more similar to humans because they are mammals, zebrafish have several advantages over their furry competitors. Why use zebrafish when you could use mice? Thus, any type of disease that causes changes in these body parts in humans could theoretically be modeled in zebrafish. Many of the genes and critical pathways that are required to grow these features are highly conserved between humans and zebrafish. Moreover, zebrafish have two eyes, a mouth, brain, spinal cord, intestine, pancreas, liver, bile ducts, kidney, esophagus, heart, ear, nose, muscle, blood, bone, cartilage, and teeth. In fact, 70% of human genes are found in zebrafish. How can you model a human disease in fish?Īlthough humans may appear to be extremely different than zebrafish, we are actually much more similar to them than you might think. ![]() ![]() If you have any issues with your order please let us know.Zebrafish, so named due to their stripes, prefer to live in large groups called shoals. We will refund or replace any livestock that arrives DOA (Dead on Arrival) but cannot guarantee your order will arrive on time since we have no control over the postage service. Please note I cannot guarantee your parcel will arrive on time, however will refund any DOA livestock. All orders placed after that time will be sent on the following Monday. Purchases for the week will be packed and sent SUNDAY - 8pm. Very large products, plant or snail orders are $9 tracked postage.Įxpress is a flat $12 no matter the order size (I will cover any extra for free).Īll live goods are sent with express post for a flat $12. If you have any questions or problems feel free to contact us!Īll small products, plant or snail orders are $3 flat postage. They like to school, so getting a few is recommended.ĭon't forget to check out our plants for combined postage and keeping the fish happy in transit! These Freshwater fish are great for almost any freshwater aquarium while having a beautiful striped pattern. ![]()
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